A simple way of mixing small volumes (microliters or milliliters) of reagents is by repeatedly dispensing and withdrawing solution from a microwell or tube. In this case study, we used a two-phase multiphysics simulation with coupled fluid flow and mass transfer to analyze the efficacy of this active mixing process.
Removing reagents or sample from a previous processing step via a wash cycle is a common challenge in microfluidic assays used in diagnostic, genomic, biomedical, pharmaceutical and other applications. This case study shows how finite element simulations may be used to predict and optimize wash cycle performance.
Controlling spatial variations in chemical concentration is important for designing and operating many microfluidic devices across a wide range of industries and applications including diagnostics, genomics, and pharmaceutics. In this case study, we show how simulations may be used to quantify and control concentration gradients in microfluidic devices.
Manufacturing variations are of critical importance in MEMS design. In this MEMS gyroscope case study, Veryst created an approach to look at the effect of a range of manufacturing variations on MEMS devices using the same mesh. We also use semi-analytic equations to enable scalable modeling of the gyroscope electrostatic actuation and pick-off (which senses the motion produced by rotation).
To compare the performance of two gas humidification devices, Veryst Engineering performed gas flow testing, device examination and CFD analysis.
Laminar static mixers are often employed in industrial environments when the mixing of two or more fluids is required. However, their performance is impossible to analyze with a pure CFD approach. Veryst, in collaboration with Nordson EFD, developed a unique computational modeling tool to evaluate and optimize the design of such mixers.
Oxygen transport is a key factor in the design of cell culture systems such as organs-on-a-chip, multiphysiological systems, and bioreactors. In this case study, we use multiphysics simulation to analyze oxygen transport and cellular uptake in a model microchannel bioreactor.
The call for structures that can selectively block acoustic waves of certain frequencies is growing, but their design is often inhibited by the lack of appropriate simulation tools in commercial FEA packages. Veryst developed a COMSOL Multiphysics model for unit cell band gap simulations, enabling the design and optimization of phononic band gap structures with target band gap width and locations.
Scaling chemical reactions from the lab to pilot or production requires a detailed understanding of the physical system, which frequently involves heat transfer, mass transfer, reaction kinetics, and fluid flow. This case study illustrates how multiphysics simulations can support design decisions involved in scaling up chemical reactors.
Dr. Mark Oliver gave a presentation entitled “Additively Manufactured Polymers: Using Testing and Simulation to Realize Reliable End-Use Parts” at AMUG 2018.
Dr. Matthew Hancock spoke at two conferences about “Modeling and Simulation of Microfluidic Devices” and "Modeling and Simulation of Microfluidic Organ-on-a-Chip Devices" in San Diego, California.
At COMSOL Day Boston, Dr. Nagi Elabbasi spoke about Multiphysics Simulation in Medical Devices and Bioengineering and Dr. Matthew Hancock spoke about Modeling and Simulation of Microfluidic Devices.
Dr. Alireza Kermani offered a webinar describing how to investigate airflow patterns and prevent airborne transmission, and explaining the benefits of CFD simulation in ventilation systems studies.
Dr. James Ransley offered a webinar on Multiphysics Modeling of MEMS. This event was sponsored by COMSOL.