In this webinar, we will review the key physical phenomena governing flow and transport in microfluidic devices, and the methods for developing accurate multiphysics models of these systems. We will present case studies of multiphysics models that couple fluid mechanics, species transport, and structural mechanics to solve real-world microfluidic design challenges, including mixing optimization, fluid-structure interaction in micropumps and microvalves, and nanoparticle self-assembly for mRNA vaccine production.