High performance liquid chromatography (HPLC) is a high pressure liquid based analytical technique used to separate, identify, and precisely quantify components in complex chemical or biological mixtures, especially in pharmaceutical, clinical, food, environmental, and forensic testing. Particle size distributions can impact HPLC performance, including column efficiency and pressure drop. In this case study, Veryst developed a multi-scale simulation of flow, dispersion, and adsorption within a chromatographic bed, accounting for particle size dispersity and intraparticle diffusion.
