To compare the performance of two gas humidification devices, Veryst Engineering performed gas flow testing, device examination, and CFD analysis.
Controlling the size of lipid nanoparticles (LNPs) in small-batch pharmaceutical processes is critical for delivery efficiency in mRNA vaccines, cancer therapies, and point-of-care diagnostics. In this case study, Veryst simulated solvent mixing and LNP self-assembly kinetics in a microfluidic mixer to predict the size distribution of LNPs across a range of process flow conditions.
An osteotome unexpectedly failed during a plastic surgery operation. Veryst was hired to explain the failure.
Oxygen transport is a key factor in the design of cell culture systems such as organs-on-a-chip, microphysiological systems, and bioreactors. In this case study, we use multiphysics simulation to analyze oxygen transport and cellular uptake in a model microchannel bioreactor.
A plastic clip used to retain a patient support failed, resulting in an occupant death. Veryst was asked to determine the cause of failure.
Radio frequency tissue ablation is a commonly used and minimally invasive tissue treatment procedure. Accurately modeling this kind of coupled multiphysics problem is often challenging. Veryst developed a COMSOL Multiphysics model accounting for heat transfer, electric field, and fluid flow to study the RF tissue ablation problem where an electrode is targeting a tissue close to a blood vessel.
Shear thickening and jamming in dense particulate suspensions can lead to undesirable processing inefficiencies and failure modes across a variety of product applications, including inkjet printer nozzles, medical autoinjectors, and porous filtration systems. In this case study, Veryst simulated the flow of a dense suspension through a syringe needle to evaluate the conditions that lead to shear jamming.
Medical devices, combination products, consumer products, and manufacturing processes often include components that slide past each other. These products and processes can fail when the friction forces between the surfaces are too high, due to surface roughness, lubrication, materials, or environmental conditions. Here Veryst introduces a specialized fixture to measure the friction between a small metal wire and three polymer materials, to select a backup supplier for dual sourcing that would maintain low friction in a medical device.
Shape memory alloys, like nickel titanium alloy (nitinol), are common in medical device applications. Nitinol is often used in fine wire form and can be difficult to test. Veryst has developed methods to test fine nitinol wires in uniaxial tension at different temperatures to obtain a stress-strain curve.
New total joint replacement prostheses often use ultra-high molecular weight polyethylene (UHMWPE) in load bearing components. Design engineers need to understand the stress and strain distributions in order to extend device life.
Veryst developed a diffusion model accounting for the different layers of the human skin in order to predict the drug concentration profile of a transdermal drug delivery process.
Permeation enhancers are used to improve drug delivery through the skin by altering the structure and dynamics of the skin. Veryst developed a finite element model of drug diffusion from an adhesive patch that accounts for the effect of permeation enhancers.
Veryst has strong acoustic simulation expertise in a wide variety of applications, including medical devices and wearable technology. In many cases, acoustic problems cannot be solved adequately using a single-physics approach, and Veryst has extensive experience in solving multiphysics problems involving acoustics.
Customized simulation applications ("apps") can simplify the product design process and accelerate its development cycle. Veryst's deep expertise with simulation and with the Application Builder in COMSOL Multiphysics enables us to build useful and reliable apps that are highly customized to our clients' needs.
Chemical reactors and bioreactors involve many layers of physics, including fluid flow, heat transfer, chemical reactions, and porous media. A deep knowledge of the underlying physical phenomena is essential when scaling up reactors.