Cavitation, the formation and collapse of vapor bubbles in a liquid due to local pressure drops, can limit performance and reliability in medical devices, energy systems, and process equipment—causing unwanted wear, vibration, and efficiency loss. In this case study, we applied high-fidelity multiphase computational fluid dynamics simulations to capture the unsteady dynamics of cavitation in confined geometries and demonstrate how simulation can guide the development of safer, more efficient, and longer-lasting products and systems.