This course—now taking place over three days—will review the physics areas relevant to medical devices and cover the efficient use of COMSOL Multiphysics to solve problems in the medical device industry. It covers modeling challenges specific to medical devices, such as biological material model
A simple way of mixing small volumes (microliters or milliliters) of reagents is by repeatedly dispensing and withdrawing solution from a microwell or tube. In this case study, we used a two-phase multiphysics simulation with coupled fluid flow and mass transfer to analyze the efficacy of this active mixing process.
Bioabsorbable materials, such as polylactic acid (PLA), are finding increasing applications in medical devices. These polymers exhibit a nonlinear anisotropic viscoplastic response when deformed, which requires a sophisticated material model for accurate finite element predictions.
Removing reagents or sample from a previous processing step via a wash cycle is a common challenge in microfluidic assays used in diagnostic, genomic, biomedical, pharmaceutical and other applications. This case study shows how finite element simulations may be used to predict and optimize wash cycle performance.
Controlling spatial variations in chemical concentration is important for designing and operating many microfluidic devices across a wide range of industries and applications including diagnostics, genomics, and pharmaceutics. In this case study, we show how simulations may be used to quantify and control concentration gradients in microfluidic devices.
Medical devices, such as the cranial perforator here, show imperfections that are rejected by physicians. Veryst investigated the source of these imperfections and recommended steps to remove them.
A commonly encountered failure mode in microfluidic devices is delamination between adjacent device layers. Veryst examined the influence of control channel geometry on the delamination pressure of a pneumatic microfluidic valve using finite element analysis.
Thermal ablation is a minimally invasive way to treat tumors, and simulating the physics of ablation can help in the design of ablation devices. Veryst designed and simulated a catheter-based acoustic ablation device relying on acoustic pressure waves to heat tissue to induce necrosis.
The nonlinear deformation and material relaxation associated with modeling the polymer screws for anterior cruciate ligament (ACL) reconstruction makes predicting key quantities such as stresses and holding forces challenging. Veryst, with its unique ability to test and model PLLA materials, was able to develop material and finite element models that predict the important short-term pull-out forces as well as the evolution of stresses over time.
Guidewires and stents can become entangled during deployment. Veryst assisted in determining whether product design plays any role in these events.
Red bloods cells may be damaged in medical devices due to high shear stresses induced by their flow through the device. Veryst simulated turbulent flow of a converging-diverging nozzle specified in an FDA benchmark study, incorporating different hemolysis models to determine which areas of the device may damage red blood cells.
To compare the performance of two gas humidification devices, Veryst Engineering performed gas flow testing, device examination, and CFD analysis.
An osteotome unexpectedly failed during a plastic surgery operation. Veryst was hired to explain the failure.
Oxygen transport is a key factor in the design of cell culture systems such as organs-on-a-chip, microphysiological systems, and bioreactors. In this case study, we use multiphysics simulation to analyze oxygen transport and cellular uptake in a model microchannel bioreactor.
A plastic clip used to retain a patient support failed, resulting in an occupant death. Veryst was asked to determine the cause of failure.