Bioengineering, Medical Devices


Multiphysics Analysis for Medical Devices Using COMSOL Multiphysics

This two-day course will cover the efficient use of COMSOL Multiphysics to solve problems in the medical device industry.  It covers modeling challenges specific to medical devices, and several examples including tissue ablation and a cardiovascular application.  The class includes technical lect

Case study

Active Mixing in a Microwell by Repetitive Pipetting
A simple way of mixing small volumes (microliters or milliliters) of reagents is by repeatedly dispensing and withdrawing solution from a microwell or tube. In this case study, we use a two-phase multiphysics simulation with coupled fluid flow and mass transfer to analyze the efficacy of this active mixing process.
Bioabsorbable Coronary Stent Design
Bioabsorbable materials, such as polylactic acid (PLA), are finding increasing applications in medical devices. These polymers exhibit a nonlinear anisotropic viscoplastic response when deformed, which requires a sophisticated material model for accurate finite element predictions.
Chemical Carryover in Microfluidic Devices
Removing reagents or sample from a previous processing step via a wash cycle is a common challenge in microfluidic assays used in diagnostic, genomic, biomedical, pharmaceutical and other applications. This case study shows how finite element simulations may be used to predict and optimize wash cycle performance.
Concentration Gradients in Microfluidic Devices
Controlling spatial variations in chemical concentration is important for designing and operating many microfluidic devices across a wide range of industries and applications including diagnostics, genomics, and pharmaceutics. In this case study, we show how simulations may be used to quantify and control concentration gradients in microfluidic devices.
Cranial Perforators
Medical devices, such as the cranial perforator here, show imperfections that are rejected by physicians. Veryst investigates the source of these imperfections and recommends steps to remove them.
Delamination in Microfluidic Valves
A commonly encountered failure mode in microfluidic devices is delamination between adjacent device layers. Veryst examined the influence of control channel geometry on the delamination pressure of a pneumatic microfluidic valve using finite element analysis.
Design and Simulation of a Catheter-Based Acoustic Ablation Device
Thermal ablation is a minimally invasive way to treat tumors, and simulating the physics of ablation can help in the design of ablation devices. Veryst designed and simulated a catheter-based acoustic ablation device relying on acoustic pressure waves to heat tissue to induce necrosis.
FEA of Absorbable PLLA Bone Screw
The nonlinear deformation and material relaxation associated with modeling the polymer screws for anterior cruciate ligament (ACL) reconstruction makes predicting key quantities such as stresses and holding forces challenging. Veryst, with its unique ability to test and model PLLA materials, was able to develop material and finite element models that predict the important short-term pull-out forces as well as the evolution of stresses over time.
Guidewire Entanglement
Guidewires and stents can become entangled during deployment. Veryst assists in determining whether product design plays any role in these events.
Insufflation Analysis
To compare the performance of two gas humidification devices, Veryst Engineering performed gas flow testing, device examination and CFD analysis.
Osteotome Fracture
An osteotome unexpectedly failed during a plastic surgery operation. Veryst was hired to explain the failure.
Plastic Clip Failure
A plastic clip used to retain a patient support failed, resulting in an occupant death. Veryst was asked to determine the cause of failure.
RF Tissue Ablation Simulation
Radio frequency tissue ablation is a commonly used and minimally invasive tissue treatment procedure. Accurately modeling this kind of coupled multiphysics problem is often challenging. Veryst developed a COMSOL Multiphysics model accounting for heat transfer, electric field, and fluid flow to study the RF tissue ablation problem where an electrode is targeting a tissue close to a blood vessel.
Total Knee Replacement
New total joint replacement prostheses often use ultra-high molecular weight polyethylene (UHMWPE) in load bearing components. Design engineers need to understand the stress and strain distributions in order to extend device life.

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