A simple way of mixing small volumes (microliters or milliliters) of reagents is by repeatedly dispensing and withdrawing solution from a microwell or tube. In this case study, we used a two-phase multiphysics simulation with coupled fluid flow and mass transfer to analyze the efficacy of this active mixing process.
Bubbles trapped in microchannels can distort the fluid flow and impact the device performance. Veryst developed a multiphase CFD model to predict the effect of geometry and surface properties on the likelihood of bubble entrapment.
Removing reagents or sample from a previous processing step via a wash cycle is a common challenge in microfluidic assays used in diagnostic, genomic, biomedical, pharmaceutical and other applications. This case study shows how finite element simulations may be used to predict and optimize wash cycle performance.
Controlling spatial variations in chemical concentration is important for designing and operating many microfluidic devices across a wide range of industries and applications including diagnostics, genomics, and pharmaceutics. In this case study, we show how simulations may be used to quantify and control concentration gradients in microfluidic devices.
A commonly encountered failure mode in microfluidic devices is delamination between adjacent device layers. Veryst examined the influence of control channel geometry on the delamination pressure of a pneumatic microfluidic valve using finite element analysis.
Veryst developed a coupled CFD mass transfer model to predict a microfluidic mixer configuration appropriate for mixing pure and salt water channels.
Oxygen transport is a key factor in the design of cell culture systems such as organs-on-a-chip, microphysiological systems, and bioreactors. In this case study, we use multiphysics simulation to analyze oxygen transport and cellular uptake in a model microchannel bioreactor.
Electroosmotic (EO) pumps are driven purely by electric fields and have no moving parts. Cascading EO pumps reduces voltage requirements. Veryst used computational fluid dynamics (CFD) and semi-analytical equivalent circuit theory to analyze the complex behavior of these pumps.
Veryst offers state-of-the-art consulting in the design and analysis of gaseous and fluid systems and products. We employ advanced CFD analysis to solve problems involving fluid mixing, multiphase flow, phase change, non-Newtonian fluids, and microfluidic effects.
Veryst offers a comprehensive approach to solving problems in microfluidic device development. We employ an array of modeling tools, such as scaling arguments, analytical formulas, computational simulations, and laboratory testing to inform the design and integration of common components.
Veryst provides expertise in many aspects of simulation and analysis for use in product design, manufacturing processes, and failure analysis. This includes modeling and analysis involving polymer materials, multiphysics modeling, finite element analysis, computational fluid dynamics, and system
Veryst’s modeling and simulation work was featured in a COMSOL blog titled “Preventing Bubble Entrapment in Microfluidic Devices Using Simulation.” The blog describes how Veryst modeled different microchannel geometries and simulated bubble movement, providing insight that can be used to improve the design of microfluidic devices.
Veryst is pleased to welcome a new member to its engineering team! Dr. Matthew Hancock, has an extensive background in fluid mechanics and model-based engineering, including microfluidics, wetting of textured surfaces, surface tension effects, heat/mass transfer, solid-fluid interaction, wave motion, and multiscale analysis.
Veryst Engineering is proud to have been a Gold Sponsor of COMSOL’s premier event: COMSOL Conference 2013 Boston.
Dr. Matthew Hancock offered a webinar addressing modeling and design processes for lab-on-a-chip and organ-on-a-chip devices and other microfluidic systems. He discussed simulation methods and related tools and demonstrated how to set up an example model of a micropump with fully (two-way) coupled fluid-structure interaction.