Active Mixing in a Microwell by Repetitive PipettingA simple way of mixing small volumes (microliters or milliliters) of reagents is by repeatedly dispensing and withdrawing solution from a microwell or tube. In this case study, we used a two-phase multiphysics simulation with coupled fluid flow and mass transfer to analyze the efficacy of this active mixing process.
Bubble Entrapment in MicrochannelsBubbles trapped in microchannels can distort the fluid flow and impact the device performance. Veryst developed a multiphase CFD model to predict the effect of geometry and surface properties on the likelihood of bubble entrapment.
Chaotic Mixing in Microfluidic DevicesFast mixing of reagents in microfluidic channels and devices is important for DNA sequencing, mRNA vaccine production in small-batch pharmaceutical processes, and point-of-care diagnostics. In this case study, Veryst used computational fluid dynamics simulations to evaluate the mixing performance of three commonly used microfluidic mixers.
Chemical Carryover in Microfluidic DevicesRemoving reagents or sample from a previous processing step via a wash cycle is a common challenge in microfluidic assays used in diagnostic, genomic, biomedical, pharmaceutical and other applications. This case study shows how finite element simulations may be used to predict and optimize wash cycle performance.
Concentration Gradients in Microfluidic DevicesControlling spatial variations in chemical concentration is important for designing and operating many microfluidic devices across a wide range of industries and applications including diagnostics, genomics, and pharmaceutics. In this case study, we show how simulations may be used to quantify and control concentration gradients in microfluidic devices.
Delamination in Microfluidic ValvesA commonly encountered failure mode in microfluidic devices is delamination between adjacent device layers. Veryst examined the influence of control channel geometry on the delamination pressure of a pneumatic microfluidic valve using finite element analysis.
Lipid Nanoparticle Self-assembly for mRNA Vaccine ProductionControlling the size of lipid nanoparticles (LNPs) in small-batch pharmaceutical processes is critical for delivery efficiency in mRNA vaccines, cancer therapies, and point-of-care diagnostics. In this case study, Veryst simulated solvent mixing and LNP self-assembly kinetics in a microfluidic mixer to predict the size distribution of LNPs across a range of process flow conditions.
Microfluidic Mixer Concentration ProfileVeryst developed a coupled CFD mass transfer model to predict a microfluidic mixer configuration appropriate for mixing pure and salt water channels.
Oxygen Transport and Cellular Uptake in a MicrochannelOxygen transport is a key factor in the design of cell culture systems such as organs-on-a-chip, microphysiological systems, and bioreactors. In this case study, we use multiphysics simulation to analyze oxygen transport and cellular uptake in a model microchannel bioreactor.
Theoretical and Numerical Analysis of Low-Voltage Cascade Electroosmotic PumpsElectroosmotic (EO) pumps are driven purely by electric fields and have no moving parts. Cascading EO pumps reduces voltage requirements. Veryst used computational fluid dynamics (CFD) and semi-analytical equivalent circuit theory to analyze the complex behavior of these pumps.
Computational Fluid Dynamics (CFD)Veryst offers state-of-the-art consulting in the design and analysis of gaseous and fluid systems and products. We employ advanced CFD analysis to solve problems involving fluid mixing, multiphase flow, phase change, non-Newtonian fluids, and microfluidic effects.
Veryst has deep expertise in fluidic mixing processes, which we leverage for our clients across industries. A fundamental aspect of mixing is the stretching and folding of the interface between initially separated substances. This occurs in many forms and systems:
MicrofluidicsVeryst offers a comprehensive approach to solving problems in microfluidic device development. We employ an array of modeling tools, such as scaling arguments, analytical formulas, computational simulations, and laboratory testing to inform the design and integration of common components.
Simulation & Analysis
Veryst provides expertise in many aspects of simulation and analysis for use in product design, manufacturing processes, and failure analysis. This includes modeling and analysis involving polymer materials, multiphysics modeling, finite element analysis, computational fluid dynamics, computatio