Species Transport

Veryst assists clients in addressing problems involving transport of chemical substances.  Our experience in species transport includes transdermal drug delivery and permeability of polymer systems.  We employ advanced computational methods to model the complex coupled interactions between solute concentrations and carrier material properties, applying appropriate simplifications for cases involving low concentration species transport.  We also develop specialized algorithms for advection-dominated mass transfer problems with very high Péclet numbers.  Our clients have used our analyses of their existing products both to understand performance and develop improvements, which in some instances has resulted in new intellectual property.

Chemical carryover in a microchannel
Chemical carryover in a microchannel

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Controlling spatial variations in chemical concentration is important for designing and operating many microfluidic devices across a wide range of industries and applications including diagnostics, genomics, and pharmaceutics. In this case study, we show how simulations may be used to quantify and control concentration gradients in microfluidic devices.

Transdermal Permeation Enhancers

Permeation enhancers are used to improve drug delivery through the skin by altering the structure and dynamics of the skin. Veryst developed a finite element model of drug diffusion from an adhesive patch that accounts for the effect of permeation enhancers.

Oxygen Transport and Cellular Uptake in a Microchannel

Oxygen transport is a key factor in the design of cell culture systems such as organs-on-a-chip, microphysiological systems, and bioreactors. In this case study, we use multiphysics simulation to analyze oxygen transport and cellular uptake in a model microchannel bioreactor.

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