Species Transport

Veryst assists clients in addressing problems involving transport of chemical substances.  Our experience in species transport includes transdermal drug delivery and permeability of polymer systems.  We employ advanced computational methods to model the complex coupled interactions between solute concentrations and carrier material properties, applying appropriate simplifications for cases involving low concentration species transport.  We also develop specialized algorithms for advection-dominated mass transfer problems with very high Péclet numbers.  Our clients have used our analyses of their existing products both to understand performance and develop improvements, which in some instances has resulted in new intellectual property.

Porous Media
Porous media

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Concentration Gradients in Microfluidic Devices

Controlling spatial variations in chemical concentration is important for designing and operating many microfluidic devices across a wide range of industries and applications including diagnostics, genomics, and pharmaceutics. In this case study, we show how simulations may be used to quantify and control concentration gradients in microfluidic devices.

Transdermal Permeation Enhancers

Permeation enhancers are used to improve drug delivery through the skin by altering the structure and dynamics of the skin. Veryst developed a finite element model of drug diffusion from an adhesive patch that accounts for the effect of permeation enhancers.

Active Mixing in a Microwell by Repetitive Pipetting

A simple way of mixing small volumes (microliters or milliliters) of reagents is by repeatedly dispensing and withdrawing solution from a microwell or tube. In this case study, we use a two-phase multiphysics simulation with coupled fluid flow and mass transfer to analyze the efficacy of this active mixing process.

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