Vial filling—the precise transfer of liquids into vials under controlled conditions—is a common process step in pharmaceutical, diagnostic, and laboratory applications, where product quality and regulatory compliance demand exceptional consistency and reliability. This case study compares two filling strategies using moving and fixed inlet nozzles, demonstrating how controlling the distance between the nozzle and the liquid surface can produce clean fills or, conversely, lead to undesirable outcomes such as dripping, splashing, and air entrainment. These results provide practical guidance for engineers seeking to refine filling protocols, minimize waste, and ensure consistently reliable production.