A simple way of mixing small volumes (microliters or milliliters) of reagents is by repeatedly dispensing and withdrawing solution from a microwell or tube. In this case study, we used a two-phase multiphysics simulation with coupled fluid flow and mass transfer to analyze the efficacy of this active mixing process.
Fast mixing of reagents in microfluidic channels and devices is important for DNA sequencing, mRNA vaccine production in small-batch pharmaceutical processes, and point-of-care diagnostics. In this case study, Veryst used computational fluid dynamics simulations to evaluate the mixing performance of three commonly used microfluidic mixers.
Laminar static mixers are often employed in industrial environments when the mixing of two or more fluids is required. However, their performance is impossible to analyze with a pure CFD approach. Veryst, in collaboration with Nordson EFD, developed a unique computational modeling tool to evaluate and optimize the design of such mixers.
Controlling the size of lipid nanoparticles (LNPs) in small-batch pharmaceutical processes is critical for delivery efficiency in mRNA vaccines, cancer therapies, and point-of-care diagnostics. In this case study, Veryst simulated solvent mixing and LNP self-assembly kinetics in a microfluidic mixer to predict the size distribution of LNPs across a range of process flow conditions.
Veryst developed a coupled CFD mass transfer model to predict a microfluidic mixer configuration appropriate for mixing pure and salt water channels.
Flash nanoprecipitation (FNP) is a novel method to produce nanoparticles for a variety of applications, including mRNA vaccine manufacturing. This case study demonstrates the high-fidelity prediction of micromixing rates, which are critical to controlling the size distribution of nanoparticles created using FNP.
Scaling chemical reactions from the lab to pilot or production requires a detailed understanding of the physical system, which frequently involves heat transfer, mass transfer, reaction kinetics, and fluid flow. This case study illustrates how multiphysics simulations can support design decisions involved in scaling up chemical reactors.
Chemical reactors and bioreactors involve many layers of physics, including fluid flow, heat transfer, chemical reactions, and porous media. A deep knowledge of the underlying physical phenomena is essential when scaling up reactors.
Veryst offers state-of-the-art consulting in the design and analysis of gaseous and fluid systems and products. We employ advanced CFD analysis to solve problems involving fluid mixing, multiphase flow, phase change, non-Newtonian fluids, and microfluidic effects.
Veryst has deep expertise in fluidic mixing processes, which we leverage for our clients across industries. A fundamental aspect of mixing is the stretching and folding of the interface between initially separated substances. This occurs in many forms and systems:
Veryst offers a comprehensive approach to solving problems in microfluidic device development. We employ an array of modeling tools, such as scaling arguments, analytical formulas, computational simulations, and laboratory testing to inform the design and integration of common components.
Accurate simulation of many products now requires a multiphysics approach. Veryst Engineering specializes in multiphysics problems involving solids, fluids, heat transfer, mass transfer, acoustics, and electromagnetics. Our modeling and analysis expertise includes fluid-structure interaction, thermal-structure interaction, structural-acoustic vibrations, conjugate heat transfer, Joule heating, and microwave heating.
Veryst Engineering, in collaboration with Nordson EFD, published an article in the 2012 COMSOL News magazine titled "Modeling of Laminar Flow Static Mixers."
Veryst was busy at this conference, a new online event. Our engineers--certified COMSOL consultants--offered a workshop on "Solving Challenging Multiphysics Problems," delivered a keynote presentation on "Modeling Flow of Exhaled Droplets between Two Runners" and presented six additional presentations on a wide-range of topics.
Recent events underscore the importance of rapid diagnostic tests for detecting viruses. Dr. Andrew Spann demonstrated the use COMSOL Multiphysics to understand and optimize the performance of different aspects of diagnostic systems, including chemical concentration gradients, chemical carryover, reagent dissolution, and mixing.